Pedunculopontine Nucleus Degeneration Contributes to Both Motor and Non-Motor Symptoms of Parkinson’s Disease
نویسندگان
چکیده
منابع مشابه
[Non-motor symptoms of Parkinson's disease].
Parkinson's disease has traditionally been viewed as a disease with only motor features. Nowadays, a wide variety of non-motor symptoms and signs are also recognised as being characteristic of the disease. Non-motor symptoms, most importantly autonomic dysfunction, neuropsychiatric symptoms and sleep problems, are prevalent in virtually all Parkinson's disease patients and influence the quality...
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The motor symptoms of Parkinson's disease (PD), bradykinesia, muscular rigidity, and tremor depend upon degeneration of the dopaminergic neurons in the substantia nigra pars compacta. Recent neuropathological studies show that the Lewy bodies, the intraneuronal landmark of PD, accumulate in several neuronal cell types in the brain. An ascending gradient of pathological involvement, from the med...
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Parkinson's disease (PD) includes motorial and non-motorial features, both negatively influencing patients’ life quality. While motor symptoms are well recognized and described, non motor symptoms are becoming a more recent focus of interest and research. This review aims to give an updated information about non-motor symptoms in PD. It comprehends three sections: 1) cognitive dysfunctions, 2) ...
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The aim of this study is to elucidate the clinical spectrum and frequency of non-motor symptoms during off periods (NMOS) in Parkinson's disease (PD) patients with motor fluctuation. We compared clinical characteristics between PD patients with motor symptoms only (M-off) and those with both motor and non-motor symptoms (NM-off) during off periods. The association of NMOS with parkinsonian clin...
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Background and objective:to identify the prevalence of non-motor symptoms (NMS) and to determine the association between NMS and motor symptoms in Thai Parkinson’s disease (PD) patients. Methods: A cross sectional study was performed in PD patients at Maharat Nakhon Ratchasima Hospital between January-June 2014. The NMS were assessed by using Non-Motor Symptoms Questionnaire-Thai version. All d...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2020
ISSN: 1663-9812
DOI: 10.3389/fphar.2019.01494